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Re-randomize scrambled numbers

In IWRS, when using scrambled randomization of subject numbers, you have an option to re-randomize the numbers in case for some reason, you are not satisfied with the previous randomization result.

To re-randomize the scrambled numbers

  1. In the IWRS application header, select the TREATMENT DESIGN tab.

  2. On the page that opens, in the left pane, select the Period subtab.

  3. In the Period List table that appears, locate the period of your interest. Then in the Period Name column, select the value to open the period configurator.

  4. In the period configurator, in the Scrambled Randomization List table, go to the scrambled randomization that you want to re-randomize and next to it, select More more_icon.png > Re-randomize refresh_icon.png.

    Re-randomizing scrambled numbers
    Figure 1. Re-randomizing scrambled numbers

    Important

    If the scrambled numbers within are not involved in any randomization scheme, Re-randomize refresh_icon.png is disabled.

Upon selecting refresh_icon.png, the scrambled numbers are randomized again. You can also edit or add new scrambled randomization.

In this section:

A set of global randomization numbers within each period of the multiperiod study used to prevent unexpected unblinding.

In IWRS, the scrambled randomization feature is only available for multiperiod studies to mix up the subject randomization numbers in each cohort so that by viewing the randomization number itself user cannot tell to which arm the randomization number belongs.